Fig. 3

Genomic difference between MEN1/DAXX^mut and MEN1/DAXX^wild group. A This chart displays the distribution of various genomic features—ploidy, MATH score, MSI, TMB, TNB, CNV counts, LOH, LST, TAI, HRD, and WGD—in primary tumors (blue, primary), lymph node metastases (orange, metastatic), and liver metastases (green, metastatic) within the MEN1/DAXXmut and MEN1/DAXX^wild groups. The vertical axes represent the values of the respective genomic features, while the horizontal axes distinguish between the MEN1/DAXX^mut and MEN1/DAXX^wild groups. Each data point corresponds to a single sample. B This chart presents the composition of de novo mutational signatures across all 75 samples. The vertical axis represents the percentage of each de novo mutational signature, with De novo Signatures 1, 2, and 3 colored in cinnabar, turquoise, and green, respectively. Sample IDs are listed at the bottom, grouped by patient IDs at the top. C The distribution of de novo Signature 1 composition in primary tumors (blue, primary), lymph node metastases (orange, metastatic), and liver metastases (green, metastatic) within the MEN1/DAXX^mut and MEN1/DAXX^wild groups is illustrated in this chart. The vertical axis represents the composition of de novo Signature 1, while the horizontal axis distinguishes between the MEN1/DAXX^mut and MEN1/DAXX^wild groups. Each data point represents a single sample. D Cosine similarity between de novo mutational signatures and COSMIC Signature V2 is visualized in this chart. The vertical axis represents the de novo signatures, while the horizontal axis represents COSMIC V2 signatures. The color of each tile in the figure indicates the cosine similarity between the horizontal COSMIC V2 signature and the vertical de novo signature, ranging from blue (lowest similarity) to cinnabar (highest similarity). E The distributions of MATH score, MSI, TMB, and CNV counts between MEN1/DAXX/ATRX^mut and MEN1/DAXX/ATRX^wild groups in the MSK-MET dataset are presented. Each data point represents a single sample, with blue dots representing pancreas primary samples, orange dots representing lymph samples, and green dots representing liver samples. The horizontal axis distinguishes between the MEN1/DAXX/ATRX^mut and MEN1/DAXX/ATRX^wild groups, while the vertical axis represents the values of the respective genomic features. F Overall survival analysis using Kaplan-Meier for patients with or without MEN1/DAXX/ATRX mutations in the MSK-MET dataset is displayed. The analysis includes all patients (n = 188) with available follow-up information