Fig. 2

Genomic profile of PanNET cohort. A Genetic profiles: the genetic profiles of 75 primary and metastatic tumor samples from 10 patients are depicted in this panel. Each line represents mutations of a single gene across all samples. The top 20 frequently mutated genes are listed in descending order on the leftmost side. The mutation frequency of each gene is indicated to the right, followed by the numbers of clonal (in green) and subclonal (in blue) mutations. Each column represents mutations in a single sample, with the sample ID and patient’s information (indicated by the colorbar) listed at the bottom. B Distribution of Nonsynonymous somatic mutations: the distribution of nonsynonymous somatic mutations is categorized into private, shared, and public mutations across all samples. Private mutations, occurring only once, are colored in apricot. Shared mutations, found in at least two samples within the same patient, are depicted in green. Public mutations, shared by all samples within one patient, are shown in navy blue. The vertical axis represents the mutation counts, while the horizontal axis displays the sample IDs (at the bottom) grouped by patient (at the top). C Proportions of private, shared, and public nonsynonymous somatic mutations: this chart illustrates the proportions of private, shared, and public nonsynonymous somatic mutations in all samples