Fig. 8

O-GlcNAcylation promotes antiviral immune response in vivo. A mRNAs of Ifnb1, Il6, Ccl5, and Cxcl10 in the spleen of WT and Sting1^−/− mice challenged with HSV-1 (5 × 10⁶ PFU / mouse) for 6 days in the presence or absence of DON (1 mg/kg) (n = 6). B and C Levels of IFN-β and IL6 in serum from WT and Sting1^−/− mice challenged with HSV-1 (5 × 10⁶ PFU/mouse) for 6 days in the presence or absence of DON (1 mg/kg) (n = 6). D and E HSV-1 RNA in the spleen (D) and histological analysis of the lung tissue in WT and Sting1^−/− mice challenged with HSV-1 (5 × 10.⁶ PFU/mouse) for 6 days (n = 6), scale bar = 100 µm (E). Data are representatives of 3 independent biological replicates. Data are means ± SEM. NS, p > 0.05, * p < 0.05, ** p < 0.001. *** p < 0.0001