Fig. 7

O-GlcNAcylation of STING activates antiviral immune response in MEFs. A and B Sting1^−/− mice were characterized by WB and qPCR. C Primary MEFs from Sting1.^−/− mice were reconstituted with WT or T229A STING. MEFs were then infected with HSV-1 (MOI = 1) for 16 h and used for detecting the transcript of Ifnb1, Il6, Tnfa, Cxcl10, and Ccl5. Data are representative of 3 independent biological replicates. Data are means ± SEM. ** p < 0.001, *** p < 0.0001