Table 2 Univariable and multivariable COX regression analysis of prognostic factors associated with OS

Gender(female vs male)

0.833(0.473–1.468)

0.528

-

-

Age (years) (< 60 vs ≥ 60)

0.588(0.331–1.045)

0.070

-

-

Tumor size (< 4 cm vs ≥ 4 cm)

0.930(0.528–1.639)

0.803

-

-

Differentiation status (well + moderate vs poor and undifferentiated)

0.631(0.369–1.077)

0.092

-

-

Depth of invasion (T1 + T2 vs T3 + T4)

0.511(0.285–0.918)

0.025

0.981(0.530–1.819)

0. 950

Lymph node metastasis (N0 vs N1 + N2)

0.195(0.100–0.379)

 < 0.0001

0.671(0.237–1.901)

0.452

TNM stage (I + II vs III + IV)

0.141(0.063–0.312)

 < 0.0001

0.212(0.058–0.768)

0.018

TMEM160 (high vs low)

2.084(1.161–3.741)

0.014

1.881(1.042–3.396)

0.036