Table 1 Signal molecules and processes related to asparagine metabolism in various cancers
From: Metabolism of asparagine in the physiological state and cancer
Cancer type | Signal molecules and processes related to asparagine metabolism (potential therapeutic targets) | References |
|---|---|---|
Leukaemia | HAP1 | [36] |
MYC | [37] | |
GCN2- ATF4 | [39] | |
ATF4-ZBTB1 | [40] | |
CHOP | [42] | |
AKT/mTORC- autophagy | [35] | |
ERK- autophagy | [35] | |
GSK3 | [52] | |
Breast cancer | cell cycle | [58] |
EMT | [60] | |
Nrf2 | [62] | |
Melanoma | BRAF-MEK-ERK-mTORC-ATF4 | [67] |
RTK | [68] | |
c-MYC- mTORC | [68] | |
GCN2-eIF4B-ATF4 | [70] | |
Lung cancer | cyclins CyclinE1-CDK2 complex | [72] |
ROS- apoptosis | [73] | |
KRAS- AKT-NRF2-ATF4 | [73] | |
eIF2B | [74] | |
autophagy | [76] | |
CRC | SOX12 | [82] |
macropinocytosis | [88] | |
p53 | [89] |