Fig. 7
From: Metabolism of asparagine in the physiological state and cancer
SOX12 and P53 affect the growth and migration of CRC cells by regulating asparagine synthesis. P53 protects CRC cells from apoptosis during asparagine deficiency; therefore, CRC cells with p53 mutations are relatively sensitive to ASNase. In addition, asparagine deficiency induces macropinocytosis in CRC cells with KRAS mutation, providing sufficient asparagine for cells to maintain the proliferation of CRC cells