Fig. 7
From: Antidepressant fluoxetine alleviates colitis by reshaping intestinal microenvironment
Fluoxetine promotes M1 macrophages to differentiate into M2 macrophages to significantly alleviate colon inflammation. A RT-qPCR results of macrophage biomarkers among M0 macrophage, LPS and IFN-γ induced M1 macrophages and IL-4 and IL-13 induced M2 macrophages. B RT-qPCR results of macrophage biomarkers in negative/DSSS/DSS + Fluoxetine groups of mice tissue. C RT-qPCR results of macrophage biomarkers in negative/LPS/LPS + Fluoxetine groups of THP-1 monocytes. D RT-qPCR results of inflammatory-associated genes in negative/LPS/LPS + Fluoxetine groups of Caco2 and HT29. E Western-blot results of intestinal barrier-associated genes in negative/LPS/LPS + Fluoxetine groups of Caco2 and HT29. F Representative fluorescent pictures of ZO-1 staining of Caco2. Scale bars represent 50 μm