Fig. 5
From: Antidepressant fluoxetine alleviates colitis by reshaping intestinal microenvironment
Clustering and pseudoprime analysis of epithelial cells from mouse intestinal mucosa. A Visualization (a UMAP plot) of epithelial single-cell transcriptomes in mouse intestinal mucosa. B A UMAP plot showing 24 clusters and population annotations of epithelial cells. C Dot plots of representative cell type-specific markers. The dot color represents the gene expression level of cells of a cluster expressing the gene; sizes represent the percentage of cells. D A UMAP plot showing 11 epithelial cell clusters. E Cell proportion distributions of 11 epithelial cell types in the intestinal mucosa of NC/DSS/DSS + Fluoxetine groups. F Pseudptime analysis of intestinal epithelial cells showing development trajectories from stem cells to enterocyte cells and paneth cells. G Gene expression dynamics for two trajectories in (E) along development pseudotime. H KEGG enrichment analysis based on marker genes in different clusters