Fig. 2

Antidepressants significantly alleviate colon inflammation. A Establishment of an ulcerative colitis animal model. The antidepressant groups were intraperitoneally injected with related drug solutions at 10 mg/kg for 100uL, while the DSS group was intraperitoneally injected with an equal volume of PBS. After 14 days, all mice in the DSS group and the antidepressant groups received 3% (wt/vol) DSS dissolved in drinking water for 7 days. B Body weight changes. C Representative images of the overall appearance and length of the colon in different groups. D DAI scores. E Representative microscopic images of H&E staining and histology scores. F RT-qPCR of the intestinal barrier and inflammation-associated genes. G Western-blot results of intestinal barrier-associated genes