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Fig. 9 | Cell Communication and Signaling

Fig. 9

From: The in vitro and in vivo depigmentation activity of coenzyme Q0, a major quinone derivative from Antrodia camphorata, through autophagy induction in human melanocytes and keratinocytes

Fig. 9

Silencing LC3 diminished CoQ0-induced antimelanogenesis in B16F10 cells. A, B Cells transfected with the control siRNA and siLC3 were treated with CoQ0 (0 or 5 μM) for the indicated duration to determine the levels of LC3B (24 h), p-MITF (4 h), MITF (4 h), and tyrosinase (24 h) proteins. The proteins were extracted after various treatments and subjected to immunoblotting. C Transfected B16F10 cells were treated with CoQ0 (0 or 5 μM, 24 h), followed by the measurement of intracellular melanin levels. The results are the mean ± SD (n=3). **p < 0.01; ***p < 0.001 compared with untreated siRNA-transfected cells. ##p < 0.01; ###p < 0.001 compared with CoQ0-treated siRNA-transfected cells.

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Cell Communication and Signaling

ISSN: 1478-811X