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Fig. 6 | Cell Communication and Signaling

Fig. 6

From: The in vitro and in vivo depigmentation activity of coenzyme Q0, a major quinone derivative from Antrodia camphorata, through autophagy induction in human melanocytes and keratinocytes

Fig. 6

CoQ0 increased AVO formation and dysregulated the Beclin-1/Bcl-2 ratio in B16F10 cells. A, B Cells were first treated with 3-MA (1 mM, 1 h) or CQ (1 μM, 1 h) and then with CoQ0 (0 or 5 μM, 24 h). A fluorescence microscope was used to visualize the formation of intracellular AVOs (under a red filter). The intensity of red fluorescence is proportional to the AVO number. C, D Cells were treated with CoQ0 (0-5 μM, 24 h). The immunoblotting assay was performed to determine Beclin-1 and Bcl-2 protein levels, and the data are presented as the ratio of Beclin-1/Bcl-2. The results are the mean ± SD (n=3). *p < 0.05; ***p < 0.001 compared with untreated cells. ###p < 0.001 compared with CoQ0-treated cells

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Cell Communication and Signaling

ISSN: 1478-811X