Fig. 1

HH Induced Alteration of Cardiac Function with severity pronounced in male mice. A-F Representative electrocardiography (ECG) and Graphical presentation of ECG parameters including; heart rate, QT, corrected QT (QTc), JT Interval, and ST Height (n = 6–8/ mice per group). G-I Representative short-axis view M-mode echocardiogram imaging and graphical presentation of ejection fraction and shortening fraction parameters (n = 4). J-K Graphical presentations of morphometric data demonstrate alterations in the ratio of body weight/heart weight (HW/BW) and body weight (BW) (n = 5–6). L-M Effect of HH on plasma BNP and ANP concentration (n = 4–5). N-O Representative Immunoblotting of GATA4 and its Graph plot (n = 3 hearts per group). P-Q Representative Wheat germ agglutinin (WGA) staining and Graphical presentation of Cardiomyocyte surface area (n = 8–12 cells per section per 4–6 heart per group). M = male; MH = male + HH; F = female; FH = female + HH. Data were analyzed using Two-way ANOVA, followed by Turkey's multiple comparison test. ***p < 0.001; **p < 0.01; *p < 0.05