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Fig. 5 | Cell Communication and Signaling

Fig. 5

From: E-cadherin variants associated with oral facial clefts trigger aberrant cell motility in a REG1A-dependent manner

Fig. 5

Impact of REG1A modulation in motile behaviour associated with OFC. (A) Representative images of the migratory phenotype of wild-type and P373R OFC cells upon treatment with siRNAs targeting REG1A. (B) Single cell trajectories throughout 24 h. (C) Overall migrating distance, (D) Mean-square displacement (MSD), and (E) diffusion rates of individual cells depleted for REG1A. (F) Velocity and (G) area of closed wound gap over time are displayed in the graphs. (H) Quantitative analysis of the distance between the initial position and the leading edge at 6 h upon device removal. # represents a significant difference between P373R siREG1A and P373R siRNA control cells (P < 0.05)

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Cell Communication and Signaling

ISSN: 1478-811X