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Fig. 3 | Cell Communication and Signaling

Fig. 3

From: E-cadherin variants associated with oral facial clefts trigger aberrant cell motility in a REG1A-dependent manner

Fig. 3

Adhesion profile associated with HDGC and OFC E-cadherin variants. (A) Representation of the ECM platform used to evaluate the attachment profile of HDGC and OFC variants. (B) Heatmap illustrating adhesive abilities of cells expressing wild-type protein or the different variants. (C) Matrix similarity analysis based on Pearson correlation data. (D) Scaled distance and (E) Pearson correlation between the wild-type profile and that of HDGC and OFC mutants. (F) Attachment of cells expressing HDGC and OFC variants normalized against the wild-type reference. ECM compositions inducing a significant difference in adhesive ability of cells are depicted in orange for OFC and in blue for HDGC. (G) Representative images of cell attachment in relevant ECM combinations

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Cell Communication and Signaling

ISSN: 1478-811X