Fig. 4

Seizures induce synaptic loss and worsen neuronal death in the hippocampus of APP/PS1 mice. A The I-O curve of hippocampal CA1. N = 3–4 mice per group, n = 7–9 slices per mouse. B and C LTP induced by high-frequency stimulation was evaluated in hippocampal CA1. N = 3–4 mice per group, n = 7–9 slices per mouse. D-F Western blot and quantitative analysis for synapse-associated proteins in the hippocampus, including PSD-95 (E) and Syn-1 (F). N = 6. G Representative images of neuronal apoptosis in the hippocampal CA1 and CA3 regions. Scale bar, 200 μm. Data were shown as means ± SEM. Two-way ANOVA for (A, C, E and F). *p < 0.05, ***p < 0.001