Fig. 3

Seizures impair behavioral performances of APP/PS1 mice. A-C The mean speed (A), time in the corner zone (B) and time in the center zone (C) in the Open Field tests. D The percentage of time to explore new objects in the NOR tests. E The percentage of spontaneous alternation in the Y maze tests. F and G The percentage of entries into the open arm (F) and time in the open arm (G) in the EPM tests. H In the MWM tests, the escape latency in the acquisition trial. I-M In the MWM tests, the number of platform crosses (I), latency to platform (J), the mean swimming speed (K), time in the target quadrant (L) and latency to target quadrant (M) during the probe test. N Representative track images of mice in the probe test. N = 11, 10, 10, 10. Data were shown as means ± SEM. One-way ANOVA for (C-G, I-M). Kruskal-Wallis test for (A and B). Two-way ANOVA for (H). *p < 0.05, ** p < 0.01, ***p < 0.001