Fig. 1

Higher susceptibility to epilepsy of APP/PS1 mice. A Experimental design of PTZ acute kindling model. B-D The latency of seizure phenotypes (B), time to reach Racine V (C) and required dose of PTZ (D) in 4-month-old WT and APP group. N = 6. E Maximal Racine score reached every 5 min within 90 min. N = 6. F Experimental design of PTZ chronic kindling model. G Maximal Racine score reached per day. N = 20. H Survival curve for PTZ chronic kindling model. N = 20. Data were shown as means ± SEM. Mann Whitney test for (B). Unpaired t test for (C, D). Two-way ANOVA for (E and G). Log-rank test for (H). *p < 0.05, ** p < 0.01, ***p < 0.001