Fig. 9

Impact of p38-inhibition (10 µM SB203580) and JNK1/2-inhibition (10 µM SP600125) on acidosis-induced changes in CCD-1092Sk cells coculture. Impact of p38-inhibition on acidosis-induced increase of COX-2 (a-b) and N-cadherin (c-d) and JNK1/2 inhibition on acidosis-induced increase of COX-2 (g-h) and N-cadherin (i-j). Representative western blots of proteins isolated from cells exposed to acidosis + 10 µM SB203580 or 10 µM SP600125 (e–f, k-l). n = 6. exposure time = 48 h