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Fig. 9 | Cell Communication and Signaling

Fig. 9

From: Pan-histone deacetylase inhibitor vorinostat suppresses osteoclastic bone resorption through modulation of RANKL-evoked signaling and ameliorates ovariectomy-induced bone loss

Fig. 9

Proposed schematic diagram for SAHA suppression on RANKL-induced osteoclastogenesis. The high affinity between SAHA and RANKL results in blockade of RANKL-RANK interaction, thereby interfering with RANKL-induced signaling cascades and osteoclastic bone resorption. Additionally, SAHA administration effectively ameliorates ovariectomy-induced bone loss in mice

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Cell Communication and Signaling

ISSN: 1478-811X