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Fig. 8 | Cell Communication and Signaling

Fig. 8

From: Pan-histone deacetylase inhibitor vorinostat suppresses osteoclastic bone resorption through modulation of RANKL-evoked signaling and ameliorates ovariectomy-induced bone loss

Fig. 8

Administration of SAHA ameliorates ovariectomy-induced bone loss in mice. A Representative 3D images of distal femurs in each group were reconstructed by Micro-CT scanner. B-E Quantitative statistics of trabecular morphological parameters, including BMD, BV/TV, Tb. N and Tb.Sp. F Representative images of distal femurs sections in each group stained with H&E and TRAcP (Scale bar = 400 μm; scale bar = 100 μm in the enlarged images). G-J Quantitative statistics of BV/TV, BS, N.Oc/BS, and Oc.S/BS. All data are shown as mean ± SD, n = 6 per group. *p < 0.05, **p < 0.01, ***p < 0.001 and ns: no significance, relative to the sham-operated group and OVX-untreated group

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Cell Communication and Signaling

ISSN: 1478-811X