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Fig. 5 | Cell Communication and Signaling

Fig. 5

From: Pan-histone deacetylase inhibitor vorinostat suppresses osteoclastic bone resorption through modulation of RANKL-evoked signaling and ameliorates ovariectomy-induced bone loss

Fig. 5

SAHA blocks RANKL-activated NF-κB and MAPK signaling pathways during osteoclastogenesis. A Representative fluorescence micrographs for nuclear translocation of P65 (Scale bar = 20 μm). P65 (green color) and nuclei (blue color). B Representative Western Blot images showing the influence of SAHA on the RANKL-mediated IκB-α degradation. C The phosphorylation levels of ERK, JNK and P38. D Quantification of IκB-α expression standardized to β-actin. E-G The proportion of phosphorylated ERK, JNK and P38 with respect to total ERK, JNK and P38. All data are presented as mean ± SD, n = 3 per group. *p < 0.05, **p < 0.01, ***p < 0.001

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Cell Communication and Signaling

ISSN: 1478-811X