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Fig. 3 | Cell Communication and Signaling

Fig. 3

From: Pan-histone deacetylase inhibitor vorinostat suppresses osteoclastic bone resorption through modulation of RANKL-evoked signaling and ameliorates ovariectomy-induced bone loss

Fig. 3

SAHA alters osteoclast gene networks and downregulates osteoclast-specific gene expression. RNA-seq was conducted with the following two groups (3 replicates per group): S3 (RANKL-induced osteoclasts) and S4 (RANKL-induced osteoclasts after SAHA treatment). A Pearson correlation coefficient analysis of high-throughput RNA-seq samples. B PCA plot of RNA-seq samples. C Volcano plot illustrating the differential expression of genes after treating with SAHA. Statistically significantly upregulated genes appear in red and downregulated genes appear in blue. D GO analysis bubble chart of osteoclastogenesis-associated gene expression profiles. E Gene heat map of osteoclastic differentiation-related genes. F-K qRT–PCR analysis of mRNA expression of Nfatc1, Mmp9, Cathepsin K, c-Fos, Acp5 and Oscar

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Cell Communication and Signaling

ISSN: 1478-811X