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Fig. 7 | Cell Communication and Signaling

Fig. 7

From: Regulation of NCOA4-mediated iron recycling ameliorates paraquat-induced lung injury by inhibiting ferroptosis

Fig. 7

Genetic inhibition of the NCOA4-FTH axis ameliorates the toxicity of paraquat in human respiratory epithelial cells. A Western blot analysis of the protein levels in control and NCOA4-silenced lung epithelial cells treated with or without PQ (500 Î¼M); B-D The detection of cell survival, cellular free iron and cellular ROS in control and NCOA4-silenced lung epithelial cells with the indicated treatment; E Western blot analysis in control and FTH-overexpressed lung epithelial cells treated with or without PQ (500 Î¼M); F-I The detection of cell survival, cellular free iron, cellular ROS, and lipid peroxides in control and FTH-overexpressed lung epithelial cells. ★★P < 0.01 between indicated groups

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Cell Communication and Signaling

ISSN: 1478-811X