Fig. 2
From: Phase separation-mediated biomolecular condensates and their relationship to tumor
Biomolecular condensates in tumor. Within the cellular milieu of tumors, an array of biomolecular condensates manifests. In the nucleus, these encompass SGs, FOs, PML bodies, protein condensates associated with DSBs formed by P53 and 53BP1, along with TFs, co-activators, and SEs-related transcriptional condensates. In the cytoplasm, condensates are constituted by P53 and the P53 family proteins, FOs, autophagosomes, and Iron death-related condensates formed by icFSP1 and FSP1. The presence and dynamics of these condensates significantly influence tumor proliferation, metastasis, and the development of treatment resistance