Fig. 7

DRD1 signaling mitigates CCI-induced histological and functional deficits via an autophagy-dependent pathway. A Representative T2 weighted MR images showing lesion volume in mouse brain after CCI in different experimental groups. B Quantification of cortical lesion volume (n = 5 each group). C Analysis of water content (n = 5 each group). D Neurological severity score (NSS, between A-68930- and vehicle-treated WT mice). E Novel object recognition (NOR). F-I Morris water maze (MWM). Graph showing hidden platform trial (E) and visible platform trials (F). Representative images (G) and quantification (H) of probe tests. D-I WT+TBI+V mice, n = 20; WT+TBI+A-68930 mice, n = 25; beclin1^-/+ +TBI+V mice, n = 25; beclin1^-/+ +TBI+A-68930 mice, n = 25. All data are mean ± SD. V, vehicle. NS, no significance