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Table 2 Phenotype of circulating cytokeratin + cells

From: Revealing role of epigenetic modifiers and DNA oxidation in cell-autonomous regulation of Cancer stem cells

Patients

Cytokeratin %

EpCam %

Oct4a %

TET2%

5hmC %

CSC Support

Treatment

1

.85

.085

.09

Not Done

Not Done

Yes

Yes

2

5.92

.03

.02

.2

4.81

No

No

3

.24

.04

.04

0

.23

Possible

Yes

4

.79

.62

.76

0

0

Yes

Yes

5

9

.51

.67

.39

0

Yes

Yes

6

15.1

.39

6.3

.1

0

Yes

Yes

7

.46

.01

.26

0

0

Yes

Yes

8

.89

.79

.27

0

.85

No

Yes

  1. Cytokeratin + cells were analyzed by gating the nucleated fraction in peripheral blood. The identified cytokeratin+ cells were further analyzed for the shown markers. CSC support was determined by analyses of the combined phenotype - EpCam and Oct4a as potential stemness, and further sustenance of CSCs with decreases in TET2 and/or 5hmC, which prevent demethylation
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Cell Communication and Signaling

ISSN: 1478-811X