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Fig. 4 | Cell Communication and Signaling

Fig. 4

From: Revealing role of epigenetic modifiers and DNA oxidation in cell-autonomous regulation of Cancer stem cells

Fig. 4

KMT2B and KMT2D in cycling quiescence of BCCs. A Overlay of upregulated genes associated in KMT2B and KMT2D knockdown BCCs with cell cycle progression patway in IPA. B Gene set enrichment analysis (GSEA) shows upregulation of the E2F targets and G2M checkpoint pathways in KMT2B knockdown and KMT2D knockdown BCCs relative to scramble BCCs. C Representative western blot for Cyclin D1, CDK6, and CDK4 in KMT2B or KMT2D KD, and scramble triple positive (T47D) BCCs. Right graphs show the normalized densities for three biological experiments. D Western blot for p38 with extracts from KMT2B and KMT2D KD BCCs or BCCs with scramble shRNA

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Cell Communication and Signaling

ISSN: 1478-811X