Table 1 The exosomal cargo mediating drug resistance in different types of cancers

miRs

miR-21

esophageal squamous cell carcinoma

STAT3

cisplatin

[25]

miR-378-3p & miR378d

Breast cancer

EZH2/STAT3

doxorubicin & paclitaxel

[26]

miR-205

Breast cancer

E2F1

tamoxifen

[27]

miR-4443

non-small cell lung carcinoma

FSP1

cisplatin

[28]

miR-3173-5p

Pancreatic ductal adenocarcinoma

ACSL4

gemcitabine

[29]

miR-21-5p

Breast cancer

S100A6

doxorubicin

[30]

miR- 301b-3p

Gastric cancer

TXNIP

cisplatin/ vincristine

[31]

lncRNAs

SNHG7

Lung adenocarcinoma

PI3K/AKT

docetaxel

[32]

CCAL

colorectal cancer

β-catenin

oxaliplatin

[33]

H19

non-small cell lung cancer

miR-615-3p/ATG7

erlotinib

[34]

Linc00969

Breast cancer

-

trastuzumab

[35]

UCA1

non-small cell lung cancer

miR-143/FOSL2

gefitinib

[36]

FOXD3-AS1

Lung cancer

PI3K/Akt

5-fluorouracil

[37]

HOTAIR

glioblastoma

miR-519a-3p/RRM1

temozolomide

[38]

PICSAR

cutaneous squamous cell carcinoma

miR-485-5p/REV3L

cisplatin

[39]

circRNAs

circWDR62

glioma

miR-370-3p/MGMT

temozolomide

[40]

circDLGAP4

Neuroblastoma

miR-143/HK2

doxorubicin

[41]

hsa_circ0014235

non-small cell lung cancer

miR-520a-5p/CDK4

cisplatin

[42]

circVMP1

non-small cell lung cancer

miR-524-5p-METTL3/SOX2

cisplatin

[43]

circUSP7

non-small cell lung cancer

miR-934/SHP2

anti-PD1

[44]

circSYT15

cervical cancer

miR-503-5p/RSF1

cisplatin

[45]

circ-PVT1

gastric cancer

miR-30a-5p/YAP1

cisplatin

[46]

Proteins

MMP14

Pancreatic ductal adenocarcinoma

-

gemcitabine

[47]

HSP gp96

Breast Cancer

p53

paclitaxel

[48]

EGFR

non-small cell lung cancer

PI3K/AKT and MAPK

osimertinib

[49]

FOSL1

colorectal cancer

ITGB4

oxaliplatin

[50]

MIF

glioma

PI3K/AKT

temozolomide

[51]

TPX2

non-small cell lung cancer

WNT/β-catenin

docetaxel

[52]

CD44

Breast Cancer

-

doxorubicin

[53]