Fig. 5
From: Tumorigenic and tumoricidal properties of exosomes in cancers; a forward look
Different stem cell types produce Exos with tumoricidal properties. Abbreviations: MiR: MicroRNA, WNT: Wingless-related integration site, CTDP: Chemotherapy drugs preloaded, AKT: Protein kinase B, TRIM59: Tripartite motif-containing 59, CXCR: C-X-C Motif Chemokine Receptor, PEG: polyethylene glycol, RHPN2: Rhophilin-2, L-PGDS: Lipocalin-type prostaglandin D synthase. TRIL: TLR4 interactor with leucine-rich repeats, BCL-2: B-cell lymphoma 2, VEGF: Vascular Endothelial Growth Factor, BAX: Bcl-2-associated X protein, MMPs: Matrix metalloproteinases, MAPK: Mitogen-activated protein kinase, PBX3: Pre-B-cell leukemia transcription factor 3, CAFs: Cancer-associated fibroblasts, MSCs: Mesenchymal stem cells, CSCs: Cancer stem cells, EMT: Epithelial-mesenchymal transition