Fig. 2
From: Tumorigenic and tumoricidal properties of exosomes in cancers; a forward look
Underlying mechanisms associated with the generation of CAFs. These cells can regulate several cancer resistance mechanisms in a paracrine manner via the release of Exos with certain cargoes. Abbreviations: Notch: Neurogenic locus notch homolog protein, TGF-β: Transforming growth factor-β, IL-6: Interleukin 6 WNT: Wingless-related integration site, HIF-1α: Hypoxia-inducible Factor 1α, NF-κB: Nuclear factor kappa-light-chain-enhancer of activated B cells, Snail: Zinc finger protein SNAI1, Slug: Zinc-Finger Protein Slug, Zeb: Zinc finger E-box-binding homeobox