Understanding immune microenvironment alterations in the brain to improve the diagnosis and treatment of diverse brain diseases

Table 1 Changes in the number of immune cells in the brain of different diseases

Diseases	Cell types	Changes	Ref.
Aging and Neurodegenerative Diseases	Microglia	M1 increase M2 decrease	[21] [21]
	CD4⁺ T cells	Increase	[81]
	B cells	Increase	[30]
MS	CD4⁺ T cells	Increase	[31]
	CD8⁺ T cells	Increase	[35, 36]
	DCs	Increase	[40]
	B cells	Increase	[42]
Infectious Diseases	T cells	Increase in early stages and persist after pathogen clearance	[51]
Infectious Diseases	B cells	increase	[57]
GBM	DCs	Increased, with decreased activity	[66]
	CD8⁺ T cells	Increased, with decreased activity	[64]
	Tregs	Increased	[64]

ISSN: 1478-811X