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Fig. 1 | Cell Communication and Signaling

Fig. 1

From: Understanding immune microenvironment alterations in the brain to improve the diagnosis and treatment of diverse brain diseases

Fig. 1

Main resident immune cells in the brain and their distribution in different brain regions. a Skull bone meninges. Lymphatic vessels shuttle through the dura mater, and immune cells in the dura mater are relatively numerous and abundant. The subarachnoid space is filled with CSF, which contains T cells, a small number of B cells, BAMs/monocytes and DCs. b Choroid plexus. Immune cells can enter the ChP matrix through fenestrated microvessels, but the tight junctions of the ChP basement membrane restrict immune cells in the ChP stroma from entering the CSF, decreasing the number and diversity of these cells in the CSF. c Perivascular space. A barrier formed by the endfeet of astrocytes separates the perivascular space from the brain parenchyma, with a small number and variety of immune cells present. Created with BioRender.com

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Cell Communication and Signaling

ISSN: 1478-811X