Table 1 Cisplatin (CDDP) EC50 values in A2780 and A2780 CIS cell lines, in A2780 CIS transfected with 2xHA-RAB7A and 2xHA-pcDNA3.1 vector, in A2780 cells after treatment with conditioned media and A2780 CIS EVs and with A2780 EVs, and in SKOV-3, SKOV-3 CIS-1 and CIS-2 resistant clones
EC50 (µM) | |
|---|---|
A2780 | 0,9875 ± 0,11 µM |
A2780 CIS | 7,2297 ± 0,7 µM (**) |
A2780 CIS 2xHA-pcDNA3.1 | 7,92 ± 0,47 μm |
A2780 CIS 2xHA-RAB7A | 3,25 ± 0,48 μm (**) |
A2780 CIS CM | 5,5397 ± 0,21 µM (***) |
A2780 CIS EVs | 5,6153 ± 0,48 µM (***) |
A2780 CIS CM W/O EVs | 1,3923 ± 0,16 µM (*) |
A2780 CIS GW4869 CM | 1,1575 ± 0,08 µM |
A2780 EVs | 0,894 ± 0,11 µM |
A2780 CCCP EVs CM | 1,15 ± 0,12 µM (*) |
SKOV-3 | 2,11 ± 0,27 µM |
SKOV-3 CIS-1 | 12,01 ± 0,75 µM (***) |
SKOV-3 CIS-2 | 8,62 ± 0,13 µM (***) |