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Fig. 9 | Cell Communication and Signaling

Fig. 9

From: Defects of mitochondria-lysosomes communication induce secretion of mitochondria-derived vesicles and drive chemoresistance in ovarian cancer cells

Fig. 9

Mitochondria-derived vesicles induce mitochondrial bioenergetic deficit in recipient chemosensitive cells. A Oxygen rate consumption (OCR) was determined in A2780 and A2780 treated with A2780 CIS CM and A2780 CIS EVs with Seahorse Mito stress kit assay. B-F Basal respiration, maximal respiration, ATP-production coupled respiration, proton leak, and spare respiration capacity were determined by Seahorse data elaboration. G-H DiI-stained EVs were detected co-localizing with mitochondria in A2780 recipient cells by live-cell imaging assay using MitoTracker Green and immunofluorescence using anti-TOM20 antibody. Data represent the mean ± SEM of at least three independent experiments. * p < 0.05; ** p < 0.01; ***p < 0.001. Scale bar = 10 μm

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Cell Communication and Signaling

ISSN: 1478-811X