Table 2 In vivo models in studying IL-17-producing Treg and IL-10-producing Th17

Conditional knockout mice (Il17a^creIl10^fl/fl or Foxp3^creRorc^fl/fl)

To illustrate the role of IL-17-producing Treg/IL-10-producing Th17 in disease progression

[213]

Cell transfer model using Tcrb^−/− or Rag1^−/− mice

To understand the impact of specific genes or various stimuli on IL-17-producing Treg or IL-10-producing Th17cell differentiation

[15]

CD45.1/2 mouse transplantation model

To illustrate the development process of IL-17-producing Tregs

[15, 19, 233]

Fate⁺ mice

To Sort IL-10-producing Th17, Th17, Treg, Tr1, and Tr1^exTh17

[11, 25, 234, 235]

Th17 iFate mice

To determine whether Th17 cells differentiated into Tr1 or other types of T cells

[11, 25]

Kaede transgenic mice

To investigate the migration of intestinal IL-17-producing Tregs to parenteral tissues in response to external stimuli such as injury or stress

[15, 236, 237]