The dynamic shifts of IL-10-producing Th17 and IL-17-producing Treg in health and disease: a crosstalk between ancient

Table 1 Investigation of IL-17-producing Treg and IL-10-producing Th17

Cell type	Source	Detection index	Method	Reference
IL-17-producing Treg	Lymph node	RORγT⁺Foxp3⁺	Flow cytometry	[18]
	Ankle joints	RORγT⁺Foxp3⁺	Immunofluorescence	[18]
	Colon and spleen	CD4⁺TGF-β⁺RORγT⁺Foxp3⁺	Flow cytometry	[19]
	Lymph node	CD4⁺RORγT⁺Foxp3⁺	Flow cytometry	[20, 21]
	Colorectal cancer	CD4⁺Foxp3⁺IL-17A⁺	Flow cytometry	[22]
	T cell in vitro	CD4⁺CD25^highFoxp3⁺IL-17A⁺	Flow cytometry	[22]
	Peripheral blood	CD4⁺Foxp3⁺IL-17A⁺	Flow cytometry	[10, 23]
	Mucosa	CD4⁺CD25⁺CD127⁻IL-17A⁺	Single-cell sequencing	[24]
IL-10-producing Th17	Small intestinal T cells in Fate⁺ mice	CD4⁺YFP⁺IL-10^GFP+IL-17A^katushka+	Flow cytometry	[25]
	T cells in vitro	CD4⁺IL-10⁺IL-17A⁺	Flow cytometry	[26,27,28]
	Peritoneal fluid	IL-10⁺IL-17A⁺	Flow cytometry	[29]

ISSN: 1478-811X