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Fig. 2 | Cell Communication and Signaling

Fig. 2

From: The dynamic shifts of IL-10-producing Th17 and IL-17-producing Treg in health and disease: a crosstalk between ancient "Yin-Yang" theory and modern immunology

Fig. 2

Regulation of IL-10-producing Th17 differentiation. Th17 cells could convert into IL-10-producing Th17, co-expressing both IL-10 and IL-17 A. Subsequently, IL-10-producing Th17 lose their IL-17 A expression and exclusively produce IL-10, referred to as Tr1exTh17 cells. Tr1exTh17 cells could further differentiate into Tr1s. TGF-β, IL-2 and IL-27 have been shown to induce IL-10-producing Th17 differentiation, whereas IL-1β, IL-6, IL-12 and IL-23 could inhibit IL-10-producing Th17 differentiation

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Cell Communication and Signaling

ISSN: 1478-811X