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Fig. 1 | Cell Communication and Signaling

Fig. 1

From: The dynamic shifts of IL-10-producing Th17 and IL-17-producing Treg in health and disease: a crosstalk between ancient "Yin-Yang" theory and modern immunology

Fig. 1

Regulation of IL-17-producing Treg differentiation. Tregs could convert into IL-17-producing Tregs, releasing both IL-10 and IL-17 A. Subsequently, IL-17-producing Treg could further convert into Th17 cells. IL-1β, IL-6 and IL-23 could induce IL-17-producing Treg differentiation through activating STAT3, whereas IL-7, IL-15, IL-35 and IL-2 may inhibit IL-17-producing Treg differentiation due to their active roles on STAT5. Activation of Wnt signaling pathway contributed to IL-17-producing Treg differentiation through upregulating Rorc expression and HIF-1α enhanced the IL-10-producing capacity in IL-17-producing Tregs. Akkermansia muciniphila induced IL-17-producing Treg differentiation through the activation of TLR4, whereas tryptophan metabolites-producing bacteria inhibit IL-17-producing Treg differentiation through AhR. In infants, a newly discovered APC (Thetis cell IV) in gut induced IL-17-producing Treg differentiation and ILC3 induced IL-17-producing Treg differentiation in adults

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Cell Communication and Signaling

ISSN: 1478-811X