Fig. 7From: GOLGA7 is essential for NRAS trafficking from the Golgi to the plasma membrane but not for its palmitoylationPotential models for GOLGA7 regulation on NRAS transport based on its different exit sites from the Golgi. (Full arrows) classical model: in the normal condition, NRAS undergoes conventional trafficking from the cis-Golgi to the trans-Golgi and then reaches the plasma membrane. In this case, GOLGA7 may regulate the anterograde trafficking of NRAS from the cis-Golgi to the trans-Golgi. In the condition of GOLGA7 depletion, the intra-Golgi transport of NRAS is disturbed and results in its accumulation at the cis-Golgi. (Dashed arrows) alternative model: in the normal condition, NRAS vesicles can bud directly from the cis-Golgi. In this case, GOLGA7 may play a role in the budding process of NRAS. In the condition of GOLGA7 depletion, the budding process of NRAS is disturbed and results in its accumulation at the cis-Golgi. Image created with BioRender.comBack to article page