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Fig. 3 | Cell Communication and Signaling

Fig. 3

From: Mechanosensitive channel of large conductance enhances the mechanical stretching-induced upregulation of glycolysis and oxidative metabolism in Schwann cells

Fig. 3

Metabolomic analysis of the effects of MscL-G22S activation on energy metabolism in SCs. A Total principal-component analysis (PCA) was conducted on overall samples to preliminarily understand the overall metabolic differences among samples and the variation degree among samples within the group. The PCA results showed the separation trend of metabolome among each group, indicating differentially expressed substrates in metabolome between sample groups. The heatmap (B) and volcanic map (C) showed significant upregulation of metabolites in SCs with MscL-G22S activation than the controls. NC, negative control; MscL, MscL-G22S-expressing SCs; NC-stretch, negative control with mechanical stretching; MscL-stretch, MscL-G22S-expressing SCs with mechanical stretching. The comparison in energy metabolite analysis between MscL-G22S-activated SCs and other controls were shown in Fig. S4-S7

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Cell Communication and Signaling

ISSN: 1478-811X