Skip to main content
Fig. 8 | Cell Communication and Signaling

Fig. 8

From: Musashi-2 potentiates colorectal cancer immune infiltration by regulating the post-translational modifications of HMGB1 to promote DCs maturation and migration

Fig. 8

Schematic diagram of the present study. This study demonstrates that the MSI2 protein directly binds to nucleotides 1403–1409 in the 3’UTR of HMGB1 to increase disulfide HMGB1 production and translation and then interacts with the cytoplasmic acetyltransferase P300 to upregulate its expression, further promoting HMGB1 acetylation at K29 and the translocation and extracellular release of K29-HMGB1, leading to immune infiltration via HMGB1-mediated maturation and migration of DCs in CRC

Back to article page

Cell Communication and Signaling

ISSN: 1478-811X