Circular RNAs and cervical cancer: friends or foes? A landscape on circRNA-mediated regulation of key signaling pathways involved in the onset and progression of HPV-related cervical neoplasms

Heydarnia, Emad; Dorostgou, Zahra; Hedayati, Neda; Mousavi, Vahide; Yahyazadeh, Sheida; Alimohammadi, Mina; Gheibi, Mobina; Heidari, Parasta; Igder, Somayeh; Mafi, Alireza; Vakili, Omid

doi:10.1186/s12964-024-01494-0

Cell Communication and Signaling

Table 1 The crosstalk between circRNAs and cervical cancer progression with a focus on signaling pathways and miRNAs that are sponged

From: Circular RNAs and cervical cancer: friends or foes? A landscape on circRNA-mediated regulation of key signaling pathways involved in the onset and progression of HPV-related cervical neoplasms

CircRNA	Oncogenic/tumor-suppressive function	Expression pattern	Target miRNA	Target signaling pathway	Biological roles in CC	Reference
CircRNF121	Oncogenic	Overexpression	miR-153-3p	Wnt/β-catenin signaling	CircRNF121 enhances cell proliferation and migration and suppresses autophagy through the miR-153-3p/ATF2 axis and wnt/β-catenin pathway	[98]
CircSAMD11	Oncogenic	Overexpression	miR-503	Wnt/β-catenin signaling	CircSAMD11 enhances CC progression, cell proliferation, migration, and invasion and inhibits cell apoptosis by regulating the wnt/β-catenin pathway through the miR-503/SOX4 axis	[99]
Hsa_circ_0003204	Oncogenic	Overexpression	_	MAPK signaling pathway	Hsa_circ_0003204 enhances cell proliferation and migration, and suppresses cell apoptosis via regulating the MAPK signaling	[100]
CircFAT1	Oncogenic	Overexpression	miR-409-3p	MAPK signaling pathway	CircFAT1 increases tumor growth and CC progression by enhancing the ERK1/2 and p38 of MAPK pathway through the miR-409-3p/CDK8 axis	[101]
Hsa_circ_0000515	Oncogenic	Overexpression	miR-326	MAPK signaling pathway	Has_circ_0000515 induces cell proliferation and invasion, while represses apoptosis and autophagy by up-regulating the ELK1 through targeting miR-326	[102]
Hsa_circ_CSPP1	Oncogenic	Overexpression	miR-361-5p	PI3K/Akt/mTOR signaling pathway	Hsa_circ_CSPP1 improves proliferation and invasion of CC through miR-361-5p/ITGB1 in PI3K-Akt signaling pathway	[103]
Hsa_circ_0001627	Oncogenic	Overexpression	miR-1225-5p	PI3K/Akt/mTOR signaling pathway	Hsa_circ_0001627 promotes CC progression via regulating the hsa_circ_0001627/miR-1225-5p/FNDC3B axis through the PI3K/mTOR pathway	[104]
Hsa_circ_0001495	Oncogenic	Overexpression	miR-526b-3p	PI3K/Akt/mTOR signaling pathway	Has_circ_0001495 increases cell proliferation and tumor growth, while decreases apoptosis by upmodulating the TMBIM6 through sponging miR-526-3p	[105]
CircCCDC134	Oncogenic	Overexpression	miR-503-5p	_	ALKBH5-mediated m6A modification of circCCDC134 leads to circCCDC134 overexpression, which enhances the CC progression and metastasis by promoting the HIF1A-induced angiogenesis	[106]
Circ_0006646	Oncogenic	Overexpression	miR-758-3p	_	Circ_0006646 improves CC progression and metastasis by enhancing the expression of RRM2 by sponging miR-758-3p	[107]
Circ_0001823	Oncogenic	Overexpression	miR-613	_	Circ_0001823 promotes cell viability and invasion leading to improved metastasis of CC by increasing the expression of RAB8A through sponging miR-613	[108]
Hsa_circ_0005358	Tumor suppressive	Under-expression	_	_	Hsa_circ_0005358 suppresses CC progression and metastasis by blocking the interaction between PTBP1 and CDCP1 and decreasing CDCP1 expression	[109]
CircLMO1	Tumor suppressive	Under-expression	miR-4291	_	CircLMO1 enhances CC metastasis by inducing ferroptosis and apoptosis of CC cells through sponging miR-4291	[110]
CircVPRBP	Tumor suppressive	Under-expression	miR-106b-5p	_	CircVPRBP suppresses CC metastasis and progression through the miR-106b-5p/TRIM3 axis	[111]
CircPVT1 (Hsa_circ_0009143)	Oncogenic	Overexpression	miR-1286	_	CircPVT1 stimulates migration and invasion, and thus pulmonary metastasis. Also, it promotes EMT by sponging miR-1286, in an exosome-dependent manner	[112]
Circ-0000745	Oncogenic	Overexpression	_	_	Circ-0000745 upregulation leads to poor differentiation and vascular/lymphatic invasion	[113]
Circ-000284	Oncogenic	Overexpression	miR-506	_	Circ-000284 induces tumor growth and invasion by sponging miR-506, and subsequent regulation of Snail-2	[97]
Circ-NRIP1	Oncogenic	Overexpression	miR-629-3p	_	Circ-NRIP1 triggers the migration and invasion by inhibiting the PTP4A1/ ERK1/2 through sponging miR-629-3p	[114]
Circ-0003204	Oncogenic	Overexpression	_	MAPK signaling pathway	Circ-0003204 induces tumor growth, migration, and invasion by regulating the MAPK signaling	[100]
CircUBAP2	Oncogenic	Overexpression	miR-361-3p	_	CircUBAP2 provokes tumor growth and metastasis by targeting the miR-361-3p/SOX4 axis	[115]
Hsa_circRNA_0001400	Oncogenic	Overexpression	miR-326	PI3K-Akt signaling pathway	Hsa_circRNA_0001400 improves CC cell proliferation and decreases apoptosis by enhancing the PI3K-Akt signaling pathway	[116]
Circ_0000263	Oncogenic	Overexpression	miR-1179	_	Circ_0000263 enhances CC progression by reducing cell apoptosis and amplifying cell proliferation through the miR-1179/ABL2 axis	[117]
CircRNA_0000285	Oncogenic	Overexpression	miR-654-3p	_	CircRNA_0000285 suppresses miR-654-3p expression leading to increased cell viability, reduced cell apoptosis, and suppressed CC progression	[118]
Hsa_circ_0001038	Oncogenic	Overexpression	miR-337-3p	_	Has_circ_0001038 induces tumor growth, migration, lymph node and myometrial invasion, while suppresses apoptosis by affecting MACC1 and CNNM3 in a miR-337-3p-dependent manner	[119]
Circ_0003221	Oncogenic	Overexpression	miR‑139‑3p	_	Circ_0003221 promotes CC angiogenesis and progression via positive enhancing of S100A14 expression through sponging miR-139-3p	[120]

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