Fig. 4
From: Mitochondrial dynamics and colorectal cancer biology: mechanisms and potential targets
Mitochondrial dynamics in the tumor microenvironment. Mitochondrial fusion–fission dynamics in macrophages and T cells correlate with their immune activity. Targeting mitochondrial dynamics in immune cells enhances antitumor immunity. Mitochondrial fusion in TECs promotes angiogenesis and hematogenous metastasis. CRC, colorectal cancer; LLPs, liquid-liquid phase separations; OPA1, optic atrophy 1; TECs, tumor endothelial cells; VEGF, vascular endothelial growth factor; WASP–WIP, Wiskott–Aldrich syndrome protein–Wiskott–Aldrich syndrome interacting protein