Fig. 3
From: Mitochondrial dynamics and colorectal cancer biology: mechanisms and potential targets
Mitochondrial fusion and CRC biology: mechanisms and potential targets. A Fusion attenuates oxidative stress-induced mitochondrial damage and inhibits the development of CAC. B Excessive fusion promotes cell proliferation, metastasis, and apoptosis resistance. 2-DG, 2-deoxy-D-glucose; ATP, adenosine triphosphate; CAC, colitis-associated cancer; CHD6, chromodomain helicase 6; CRC, colorectal cancer; GSK3β, glycogen synthase kinase-3β; OPA1, optic atrophy 1; OPWPs, oil production waste products; OXPHOS, oxidative phosphorylation; TCA, tricarboxylic acid cycle; TMEM65, transmembrane protein 65