Fig. 2
From: Mitochondrial dynamics and colorectal cancer biology: mechanisms and potential targets
Mitochondrial fission and CRC biology: mechanisms and potential targets. AÂ Fission promotes cell proliferation, metastasis, and drug resistance. BÂ Excessive fission triggers mitochondria-mediated apoptosis. AMPK, AMP-activated protein kinase; CDK1, cyclin-dependent kinase 1; CRC, colorectal cancer; Drp1, dynamin-related protein 1; ERK, extracellular signal-regulated kinase; FIS1, mitochondrial fission protein 1; FAs, fatty acids; JNK, Jun N-terminal kinase; LATS2, large tumor suppressor kinase 2; LKB1, Liver kinase B1; MCU, mitochondrial calcium uniporter; MEK, mitogen-extracellular activated protein kinase; Mff, mitochondrial fission factor; MIEF, mitochondrial elongation factor 1; MMP, mitochondrial membrane potential; mPTP, mitochondrial permeability transition pore; MTFR2, mitochondrial fission regulator 2; OPA1, optic atrophy 1; OXPHOS, oxidative phosphorylation; PDK1, pyruvate dehydrogenase kinase 1; PTEN, phosphatase and tensin homolog; RAGE, receptor advanced glycation end product; ROS, reactive oxygen species; SIRT, Sirtuin; TCA, tricarboxylic acid cycle