Fig. 1
From: Mitochondrial dynamics and colorectal cancer biology: mechanisms and potential targets
Mitochondrial structure and fusion–fission dynamics. A Mitochondrial structure, the mitochondrial lumen (matrix) is surrounded by the OMM and IMM. B Mitochondrial fusion involves outer membrane fusion and inner membrane fusion, facilitating ATP production and exchange of matrix content. C Mitochondrial fission involves ER interactions, Drp1 recruitment and constriction, and auxiliary segmentation of Dynamin 2, promoting ROS production, clearance of damaged mitochondria by autophagy, and equitable inheritance. ATP, adenosine triphosphate; Drp1, dynamin-related protein 1; ER, endoplasmic reticulum; FIS1, mitochondrial fission protein 1; IMM, inner mitochondrial membrane; Mff, mitochondrial fission factor; Mfn, mitofusins; OMM, outer mitochondrial membrane; OPA1, optic atrophy 1; ROS, reactive oxygen species