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Fig. 8 | Cell Communication and Signaling

Fig. 8

From: MyD88 in myofibroblasts enhances nonalcoholic fatty liver disease-related hepatocarcinogenesis via promoting macrophage M2 polarization

Fig. 8

Myofibroblast dependent CCL15 is associated with shorter survival of patients with HCC. A Double staining of MyD88 and CCL15 in tumor tissues and adjacent paracancerous tissues from HCC samples. Scale bar, 50 μm. B-C Boxplots showing the expression levels of CCL15 in the liver dataset GSE164760. B Healthy: n  = 6; NASH: n  = 74; Tumor: n  = 53. C Nontumor: n  = 29; Tumor: n  = 53. D-E Spearman’s correlation analysis showed correlations among α-SMA, CCL15 and CCR1 in the liver dataset GSE164760 and GSE190967. F-I Kaplan-Meier curve for survival in the HCC TCGA dataset with MyD88, α-SMA and CCL15, combined MyD88/α-SMA/CCR1 gene expression bifurcated by the spline method to group into low vs. high. Three years and five years are indicated as dotted lines. J Schematic of MyD88 signaling in myofibroblasts in the model of NAFLD-related HCC

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Cell Communication and Signaling

ISSN: 1478-811X