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Fig. 6 | Cell Communication and Signaling

Fig. 6

From: MyD88 in myofibroblasts enhances nonalcoholic fatty liver disease-related hepatocarcinogenesis via promoting macrophage M2 polarization

Fig. 6

Secreted CCL9 was critical for DEN/HFD induced hepatocarcinogenesis.  RNA sequencing analysis of DEGs between DEN/HFD-induced liver cancer tissues from MyD88 fl/fl and SMA MyD88−/− mice. A Volcano diagram of DEGs, the threshold is padj < 0.05 and the absolute value of log2 Ratio ≥ 1. B KEGG enriched signal pathway analysis with down-regulated genes in liver tissues. C Heatmap view of the most significant differential expressed genes. D Fat accumulation related gene expression in liver tissues. E Gene expression in liver tissues. F Immunofluorescence double staining for CCL9 and α-SMA in liver cancer tissues from MyD88 fl/fl and SMA MyD88−/− mice. Scale bar. 50 μm. *p<0.05. G The protein levels of CCL15 in LX-2 medium were measured using ELISA. *p<0.05

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Cell Communication and Signaling

ISSN: 1478-811X