Fig. 9
From: Egr-1 is a key regulator of the blood-brain barrier damage induced by meningitic Escherichia coli
Schematic presentation of meningitic E. coli induction of Egr-1 for BBB disruption as well as neuroinflammatory responses. Infection of BMEC with meningitic E. coli rapidly induces expression of the host transcription factor Egr-1. Egr-1 facilitates the activation of RhoA, Rac1, and Cdc42 and promotes the expression of VEGFA, PDGFB, and ANGPTL4 to alter the cytoskeleton and degrade TJ proteins, leading to BBB breakdown. In addition, Egr-1 is a key regulatory molecule in the induction of neuroinflammation as well as the activation of microglia and astrocytes by meningitic E. coli